Welcome to the Tsubata Lab Website!
Adaptive immune responses to non-protein antigens, such as nucleic acids and glycans, play important roles in both protection against infections and the development of autoimmunity. However, the mechanisms underlying these responses differ from those involved in reactions to conventional protein antigens. Our research group is working to elucidate the mechanisms of immune responses and self-tolerance of B lymphocytes (B cells) to non-protein antigens. Based on our findings, we are also developing novel therapeutic drugs for autoimmune diseases, as well as vaccine-based treatments designed to induce antibody production as alternatives to therapeutic antibodies. We welcome collaboration with researchers and companies interested in this field of study, and we also encourage students to join our research group.
What's New
- 2026.3.25
A paper by Wang Long and colleagues on the novel strategy to regulate autoimmune diseases and graft rejection by expanding regulatory B cells was published in PLoS Biology, and a press release has been issued.
Paper: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3003681
Press release (Nihon University) (Japanese): https://www.dent.nihon-u.ac.jp/faculty/news/information/1122/
Press release (Institute of Science Tokyo) (Japanese): https://www.isct.ac.jp/ja/news/fgprv35etg1x
- 2026.1.9-11
The 6th Japan–Taiwan Bilateral Symposium on Protein Phosphatases, for which Prof. Tsubata served as an organizer on the Japanese side, was held in Tainan.
- 2025.6.1
Congratulations to former graduate student Dr. Yuki Hitomi on being promoted to Associate Professor at Department of Biometry and Genetics, Institute of Biomedical Sciences, Fukushima Medical University
- 2025.4.1
Congratulations to former PhD student Dr. Taishi Onodera on being promoted to Laboratory Chief in National Institute of Infectious Disease
- 2025.2.1
Our research was presented at the Nihon University Web Workshop under the title “Mechanisms for Preventing Autoimmune Diseases.” A 5-minute YouTube video (linked here) provides a clear and accessible synopsis of our findings.
Contact
Tsubata Lab
Nihon University School of Dentistry 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
Email : tsubata.imm@mri.tmd.ac.jp
Email : tsubata.takeshi@nihon-u.ac.jp