Welcome to the Tsubata Lab Website!
Adaptive immune responses to non-protein antigens, such as nucleic acids and glycans, play important roles in both protection against infections and the development of autoimmunity. However, the mechanisms underlying these responses differ from those involved in reactions to conventional protein antigens. Our research group is working to elucidate the mechanisms of immune responses and self-tolerance of B lymphocytes (B cells) to non-protein antigens. Based on our findings, we are also developing novel therapeutic drugs for autoimmune diseases, as well as vaccine-based treatments designed to induce antibody production as alternatives to therapeutic antibodies. We welcome collaboration with researchers and companies interested in this field of study, and we also encourage students to join our research group.
What's New
- 2025.4.1
Congratulations to former PhD student Dr. Taishi Onodera on being promoted to Laboratory Chief in National Institute of Infectious Disease
- 2025.2.1
Our research was presented at the Nihon University Web Workshop under the title “Mechanisms for Preventing Autoimmune Diseases.” A 5-minute YouTube video (linked here) provides a clear and accessible synopsis of our findings.
- 2025.1.1
Congratulations to former PhD student and postdoc Dr. Chisato Wakabayashi on being appointed as Professor at Ohu University School of Pharmacy
- 2024. 9.1
A paper by Chizuru Akatsu and colleagues on the regulation of CD22 by glycan cis-ligands was published in the Journal of Biological Chemistry.
Link to the paper: https://doi.org/10.1016/j.jaut.2024.103245
- 2024.5.22
A paper by Chizuru Akatsu and colleagues on the regulation of systemic lupus erythematosus-specific autoantibody production was published in The Journal of Autoimmunity, and a press release has been issued.
Press release: https://www.tmd.ac.jp/press-release/20240522-3/
Contact
Tsubata Lab
Nihon University School of Dentistry 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan
Email : tsubata.imm@mri.tmd.ac.jp
Email : tsubata.takeshi@nihon-u.ac.jp